• Angiology · Sep 2015

    Comparative Study Observational Study

    Comparison of Serum Cystatin C and Creatinine Level Changes for Prognosis of Patients After Peripheral Arterial Angiography.

    • Yanjiao Yang, Xiaojiao Zhao, Xiao Tang, Jianxin Lu, Minjie Zhou, Wenji Wang, Lixin Wang, Daqiao Guo, and Feng Ding.
    • Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
    • Angiology. 2015 Sep 1; 66 (8): 766-73.

    AbstractWe compared changes in serum cystatin C (Cys C) and creatinine (sCr) levels for detecting contrast-induced acute kidney injury; 350 consecutive patients who underwent peripheral arterial angiography were prospectively enrolled. Serum Cys C and sCr levels were assayed at predefined time points after contrast-media exposure. During 1-year follow-up, major adverse events (MAEs) including all-cause mortality and dialysis were assessed. A sCr increase ≥25% was not associated with MAEs, whereas a serum Cys C increase ≥5% at 24 hours was associated with higher probability of MAEs (P = .010). The independent predictors of 1-year MAEs were older age (P = .004), lower prealbumin levels (P = .022), and serum Cys C increase ≥5%. In patients who underwent peripheral angiography, a serum Cys C increase ≥5% was an independent predictor of 1-year MAEs.© The Author(s) 2014.

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