• Plast. Reconstr. Surg. · Jun 2014

    Autologous fat grafting alleviates burn-induced neuropathic pain in rats.

    • Shu-Hung Huang, Sheng-Hua Wu, Kao-Ping Chang, Kuang-I Cheng, Su-Shin Lee, Aij-Lie Kwan, Jwu-Lai Yeh, Hung-Pei Tsai, Sin-Daw Lin, and Chung-Sheng Lai.
    • Kaohsiung, Taiwan From the Graduate Institute of Medicine, the Department of Surgery, Faculty of Medicine, and the Department and Graduate Institute of Pharmacology, College of Medicine, Kaohsiung Medical University; the Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University; and the Department of Anesthesia, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University.
    • Plast. Reconstr. Surg. 2014 Jun 1; 133 (6): 1396-405.

    BackgroundThe management of neuropathic pain after burn injury is a critical clinical issue. Autologous fat grafting has been shown to alleviate neuropathic pain in certain cases, but has not been shown to alleviate the pain associated with burn-induced scars. The authors assessed the effectiveness of autologous fat grafting for the management of pain in burn-induced scars.MethodsOne paw of the experimental rats received a third-degree burn using a heated metal block. Neuropathic pain in the affected paw was assessed based on behavioral responses to thermal and mechanical stimuli. A graft (0.4 ml of autologous fat or a sham graft) was administered by injection to the burn scar and sham-burned paw. The animals were killed 4 weeks after the fat graft treatments; Masson trichrome stain of hind-paw skin and expression of phosphorylated p38 and OX42 in the dorsal horns of the spinal cords were examined.ResultThe third-degree burns were completely healed at 4 weeks. Burn-induced scarring caused mechanical allodynia and increased the expression of phosphorylated p38 and OX42 in spinal cord dorsal horn microglial cells. Autologous fat grafting significantly alleviated mechanical allodynia (p < 0.05), and immunohistochemistry showed that the expression of phosphorylated p38 and OX42 was significantly lower in spinal cord dorsal horn microglial cells 4 weeks after fat grafting (p < 0.05).ConclusionsAutologous fat grafting is used daily in clinical practice. It is an effective treatment for the relief of burn-induced mechanical allodynia in rats. Further investigation of the clinical use of autologous fat grafting in burn patients is warranted.

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