• P Fernández, M Andruskevicius, and F Cristiani.
• Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad de la República, Uruguay. paulofechaves@hotmail.com
• Rev Esp Anestesiol Reanim. 2010 Feb 1; 57 (2): 71-8.

BackgroundNitrous oxide (N2O) is a medicinal gas that has been used for anesthesia for over a century and a half. As evidence of the adverse effects of N2O have been contrasted with the good safety profiles of new anesthetic agents, use of the older gas has declined.ObjectiveTo describe and analyze the use of N2O for anesthesia in the Eastern Republic of Uruguay. To describe the use of other drugs for general anesthesia.MethodsThe study had 2 phases. In the first phase, information on the use of N2O and other drugs for general anesthesia was obtained from the medical records of a sample of patients who underwent surgery between November 2007 and November 2008 at nationally important hospitals. In the second phase 80 physician anesthesiologists were surveyed to obtain information on their reported use of N2O for general anesthesia. The respondents were found working during the first half of 2008.ResultsA total of 104 patients' records were read and 80 anesthesiologists were surveyed. We found that 31 (29.8%) patients received N2O during anesthesia. The survey showed that 62 (77.5%) of the anesthesiologists had used N2O in the last 6 months. Nine (50%) of the anesthesiologists who had not used N2O said their reason was that it was unavailable. The other 9 referred either to the risk of postoperative nausea and/or vomiting (n = 6) or the fact of having better alternatives (n = 9).ConclusionThis study shows that N2O is little used in current anesthesia practice. The tendency in Uruguay continues to be toward declining use.

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