• Tamara L Grubb, John W Schlipf, Thomas W Riebold, Christopher K Cebra, Lisa Poland, Xenia Zawadzkas, and Nicole Mailhot.
• Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
• J. Am. Vet. Med. Assoc. 2003 Oct 15; 223 (8): 1167-9.

ObjectiveTo determine the minimum alveolar concentration (MAC) of sevoflurane in spontaneously breathing llamas and alpacas.DesignProspective study.Animals6 healthy adult llamas and 6 healthy adult alpacas.ProcedureAnesthesia was induced with sevoflurane delivered with oxygen through a mask. An endotracheal tube was inserted, and a port for continuous measurement of end-tidal and inspired sevoflurane concentrations was placed between the endotracheal tube and the breathing circuit. After equilibration at an end-tidal-to-inspired sevoflurane concentration ratio > 0.90 for 15 minutes, a 50-Hz, 80-mA electrical stimulus was applied to the antebrachium until a response was obtained (ie, gross purposeful movement) or for up to 1 minute. The vaporizer setting was increased or decreased to effect a 10 to 20% change in end-tidal sevoflurane concentration, and equilibration and stimulus were repeated. The MAC was defined as the mean of the lowest end-tidal sevoflurane concentration that prevented a positive response and the highest concentration that allowed a positive response.ResultsMean +/- SD MAC of sevoflurane was 2.29 +/- 0.14% in llamas and 2.33 +/- 0.09% in alpacas.Conclusions And Clinical RelevanceThe MAC of sevoflurane in llamas and alpacas was similar to that reported for other species.

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