• Molecules · Jan 2013

    Two new koumine-type indole alkaloids from Gelsemium elegans Benth.

    • Mingxue Sun, Xiaoli Hou, Huanhuan Gao, Junsheng Guo, and Kai Xiao.
    • Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
    • Molecules. 2013 Jan 1; 18 (2): 1819-25.

    AbstractTwo new indole alkaloids, 21-oxokoumine (1) and furanokoumine (2), were isolated from the roots of Gelsemium elegans Benth together with three known compounds. The structures of the two novel compounds were elucidated by spectroscopic methods, including NMR, HR-ESI-MS, UV, IR, CD and molecular modeling. Compound 1 is the first instance of a koumine-type alkaloid with a carbonyl at the C-21 position, while compound 2 possesses a tetrahydrofuran ring located on C-20 and C-21.

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