• Gustavo Fabregat, José De Andrés, Vicente L Villanueva-Pérez, and Juan M Asensio-Samper.
• *Multidisciplinary Pain Management Department †Critical Care and Multidisciplinary Pain Management Department, School of Medicine of Valencia, General University Hospital, Valencia, Spain.
• Clin J Pain. 2013 Nov 1;29(11):1006-12.

ObjectiveBotulinum toxin is a neurotoxin that has been widely used in chronic pain for the treatment of multiple conditions with a component of localized muscle spasm. Recent studies suggest that botulinum toxin is effective in the treatment of neuropathic pain syndromes such as postherpetic neuralgia or painful scars.MethodsWe searched the PubMed and OvidSP databases. We also included cross-referencing bibliographies from primary and review articles.DiscussionIn this descriptive review, we evaluate the usefulness, safety, and potential pathophysiological mechanism of botulinum toxin type A for treatment of painful disorders with neuropathic component such as postherpetic neuralgia, diabetic neuropathy, or trigeminal neuralgia.ConclusionsOn the basis of the analysis of the reports published in the literature, it would seem that fractioned peripheral subcutaneous and perineural injections of botulinum toxin type A may be useful for the treatment of various chronic pain conditions with neuropathic component.

12 keywords...

hide…