• Thomas Müller, Matthias Lubnow, Alois Philipp, Wulf Schneider-Brachert, Daniele Camboni, Christof Schmid, and Karla Lehle.
• Department of Internal Medicine II, Institute for Medical Microbiology and Hygiene, University Medical Center of Regensburg, Franz-Josef-Strauss Allee 11, Regensburg, Germany. thomas.mueller@klinik.uniregensburg.de
• Artif Organs. 2011 Apr 1; 35 (4): E84-90.

AbstractExtracorporeal membrane oxygenation (ECMO) is the ultimate treatment option to improve gas exchange and decrease the aggressiveness of mechanical ventilation in septic patients with uncontrolled severe lung failure. However, potential microbiological colonization of the artificial surfaces of membrane oxygenator (MO) remains a critical issue in patients with bacteremia. The current study investigates the risk of MO infection in 10 consecutive septic patients on long-term treatment with ECMO. The flushing fluids of all investigated MOs were sterile. After incubation with nutrient solution for 14 days in one MO Enterococci spp. were isolated. In the patient concerned, a diffuse, unaccountable bleeding diathesis had developed, which stopped after exchange of the MO. Analysis of clinical parameters showed that D dimers had increased and fibrinogen levels had decreased before exchange of this MO, but standard markers of infection had remained unremarkable. In conclusion, circuit infection may be a potential cause for unexplained clinical deterioration of patients on ECMO, which therefore should be considered as an indication for exchange of the device.© 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

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