• Hanjian Du, Bing Xie, Peigang Lu, Hua Feng, Jian Wang, and Shaoji Yuan.
• Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, China. Electronic address: duhanjian@gmail.com.
• J Neuroradiology. 2014 May 1; 41 (2): 131-5.

Background And PurposeThe present study was designed to map alterations in brain white-matter in photosensitive epilepsy (PSE) by applying tract-based spatial statistics (TBSS) analysis.MethodsDiffusion tensor-imaging (DTI) data from MRI brain scans were collected from eight PSE patients and 16 gender- and age-matched non-epileptic controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI scans were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) values in the PSE and control groups were compared using TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement.ResultsCompared with the control subjects, the corpus callosum of PSE patients had significantly lower FA values.ConclusionOur DTI study indicates that white-matter in the corpus callosum was abnormal in PSE patients, and that DTI methods can serve as useful non-invasive tools to evaluate white-matter changes in PSE patients.Copyright © 2013 Elsevier Masson SAS. All rights reserved.

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