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Comparative Study
Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury.
- Poli Francois Kouya, Jing-Xia Hao, and Xiao-Jun Xu.
- Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Huddinge University Hospital, Karolinska Institute, S-141 86 Huddinge, Sweden.
- Eur. J. Pharmacol. 2002 Aug 16; 450 (1): 49-53.
AbstractWe have studied and compared the antinociceptive and anti-hyperalgesic effect of the partial opioid receptor agonist buprenorphine in normal and neuropathic rats. In normal rats, systemic buprenorphine produced dose-dependent antinociception on the hot plate test. In rats with peripheral nerve or spinal cord injury, buprenorphine markedly alleviated neuropathic pain-related behaviors, including mechanical and cold allodynia/hyperalgesia at doses comparable to that producing antinociception. The results suggest that buprenorphine may be a useful analgesic for treating neuropathic pain and thus is an atypical opioid since morphine tends to be less potent after nerve injury.
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