• Arch Cardiol Mex · Jan 2004

    Review

    [Electrocardiogram in channel disorders].

    • Jesús Antonio González-Hermosillo.
    • Departamento de Electrofisiología Cardíaca, Instituto Nacional de Cardiología, Ignacio Chávez INCICH, Juan Badiano No. 1 Col. Sección XVI, Tlalpan 14080 México, D.F.
    • Arch Cardiol Mex. 2004 Jan 1; 74 Suppl 1: S79-83.

    AbstractThe ion channel diseases of the heart are a collection of genetically distinct arrhythmogenic cardiovascular disorders resulting from mutations in fundamental cardiac ion channels that orchestrate the action potential of the human heart. Our understanding of these genetic "channelopathies" has increased dramatically from electrocardiographic depictions of QT prolongations, ST-T alterations and torsades de pointes and clinical descriptions of people experiencing syncope and sudden death to molecular revelations of perfurbed ion channel genes. These exciting molecular breakthroughs have provided new opportunities for translational research with investigations into genotype-phenotype correlations and gene targeted therapies.

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