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Fundam Clin Pharmacol · Aug 2009
Underlying mechanism of penehyclidine hydrochloride on isolated rat uterus.
- Hong-tao Xiao, Zhi Liao, Xian-min Meng, Xiao-yan Yan, Shu-jie Chen, and Zheng-ji Mo.
- Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial Peoples Hospital, 610072 Chengdu, China. xht927@163.com
- Fundam Clin Pharmacol. 2009 Aug 1; 23 (4): 419-21.
AbstractWe investigated the underlying mechanisms of penehyclidine hydrochloride (PHC), a novel selective anticholinergic drug on isolated rat uterus. The method of radio-immunity assay was further employed to determine cyclic adenosine mono phosphate (cAMP) levels in isolated rat uterus for comparing with selective effect on muscarinic receptor subtypes. In the assay, PHC could decrease the content of cAMP in isolated rat uterus, but the difference was not statistically significant at dose of 10 mumol/L. In conclusion, our results suggested that PHC has no or poor effect on M(2) receptor subtypes in isolated rat uterus.
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