• Paul Hobeich, Stephen Simon, Emit Schneiderman, and Jianing He.
• Department of Endodontics, Baylor College of Dentistry, Texas A&M University System Health Science Center, Dallas, Texas 75246, USA.
• J Endod. 2013 May 1; 39 (5): 597-9.

IntroductionLocal anesthetics can be buffered to a physiological pH before injection to decrease the time of onset and reduce injection pain.MethodsThirty subjects with intact maxillary canines were included. The subjects randomly received, in a double-blind manner, 1 of the 3 maxillary infiltration injections of 1.8 mL 2% lidocaine with 1:100,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine buffered at 5% and 10% with sodium bicarbonate by volume at 3 separate appointments. Pain on needle penetration and deposition of anesthetic solution was recorded by using a Heft-Parker visual analogue scale. Anesthetic onset was determined by 2 consecutive negative responses to electronic pulp test.ResultsThe mean anesthetic onset for nonbuffered anesthetics was 119 seconds, 116 seconds for the 5% buffered solutions, and 121 seconds for the 10% buffered solutions. There was no significant difference between the 3 groups. There was also no significant difference in pain on needle penetration or anesthetic deposition between the 3 anesthetic solutions tested.ConclusionsTwo percent lidocaine with 1:100,000 epinephrine buffered with 5% or 10% sodium bicarbonate did not differ from nonbuffered solutions in anesthetic onset or injection pain in maxillary infiltrations of canines with healthy pulps.Copyright © 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

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