• Research in virology · Nov 1989

    High concentrations of 2-5A, the interferon intracellular mediator, in the blood of children with acute viral infections.

    • A Luxembourg, L Laurence, M Tardieu, J M Garnier, E Dussaix, and H Cailla.
    • Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.
    • Res. Virol. 1989 Nov 1; 140 (6): 593-604.

    AbstractWe measured the concentration of 2-5A (2',5'-oligoadenylate), an intracellular mediator of the antiviral action of interferon, in the blood of children with acute viral and bacterial infectious diseases. 2-5A concentration was found to be elevated in several children with viral diseases. This elevation seemed transient and was not specific for viral infections. We provide arguments for the use of 2-5A as a marker of the evolution of diagnosed viral diseases.

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