• Rev Neurol France · Feb 2006

    Case Reports

    [Cryptococcal meningo-encephalitis in an apparently immunocompetent patient].

    • K Bretaudeau, O Eloy, A Richer, F Bruneel, D Scott-Algara, O Lortholary, and F Pico.
    • Service de Neurologie, CH de Versailles, Hôpital A. Mignot, Le Chesnay.
    • Rev Neurol France. 2006 Feb 1; 162 (2): 233-7.

    IntroductionCryptococcal meningo-encephalitis is a rare disease occurring more frequently in immunocompromised hosts.Case ReportWe report the case of an apparently immunocompetent patient who developed a recurrent neurological deficit with lymphocytic meningitis. The time from the first symptoms to diagnosis was 8 months. We noted mild CD4+ lymphocytopenia (500 cells/mm3) without HIV infection. CD4+ lymphocytes were not reactive for a panel of antigens.ConclusionThis case illustrates the usefulness of cerebrospinal fluid Cryptococcus Neoformans antigen test in patients with an unexplained neurological syndrome with a lymphocytic meningitis together with quantification of circulating lymphocytes clusters and analyse of their function in opportunistic infections.

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