-
Zhong Xi Yi Jie He Xue Bao · Sep 2007
[Effects of Astragalus on expression of renal angiopoietin receptor Tie-2 in diabetic rats].
- Hong-wei Gu, Zhao-hui Ni, Le-yi Gu, Yu-cheng Yan, Hui-li Dai, Ning-li Li, Min-fang Zhang, and Jia-qi Qian.
- Department of Nephrology, Renji Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200127, China.
- Zhong Xi Yi Jie He Xue Bao. 2007 Sep 1; 5 (5): 536-40.
ObjectiveTo study the expression of angiopoietin receptor Tie-2 in the renal tissue of diabetic rats and the effects of Astragalus.MethodsSD rats were randomly divided into normal control group, diabetes group and Astragalus-treated group. The expression of receptor Tie-2 in the renal tissue was assessed by using real-time quantitative polymerase chain reaction and immunohistochemical method.ResultsGlomerule Tie-2 protein expression was significantly elevated in the diabetes group as compared with the normal control group (P<0.01). Glomerule Tie-2 protein expression in the Astragalus-treated group was decreased as compared with the diabetes group (P<0.01).ConclusionTie-2 may play an important role in the pathogenesis of the early stage diabetic renal injury. The reno-protection effect of Astragalus may be mediated by down-regulating the expression of Tie-2 in the kidney tissue of diabetic rats.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..