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- At Kukoyi, Sa Coker, Ld Lewis, and Dw Nierenberg.
- Department of Anesthesiology, Johns Hopkins Hospital, Baltimore, MD, USA.
- Hum Exp Toxicol. 2013 Jan 1; 32 (1): 107-10.
AbstractProlonged infusion of dexmedetomidine, an α(2)-adrenoreceptor agonist anesthetic used in the intensive care unit, produces a withdrawal syndrome of sympathetic over-activity, characterized by tachycardia, hypertension and agitation, but there is no recommended standard treatment for this syndrome. We describe two patients with a clinical diagnosis of acute dexmedetomidine withdrawal and its management with oral clonidine. We utilized the principle of managing acute drug withdrawal with longer acting medications. These two cases demonstrated the benefit of using oral, longer acting clonidine to manage acute withdrawal from shorter-acting, intravenous dexmedetomidine.
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