• Roberto Casale, Fabiola Atzeni, Ignazio Francesco Masala, and Piercarlo Sarzi-Puttini.
• Habilita Care & Research Hospitals, Rehabilitation Institute of Zingonia, Via Bologna N°1, 24040 Zingonia, Italy. Electronic address: roberto.casale@fsm.it.
• Best Pract Res Clin Rheumatol. 2015 Feb 1; 29 (1): 71-6.

AbstractComplex regional pain syndrome (CRPS) encompasses a wide range of painful conditions, but it is characterised by continuing (spontaneous and/or evoked) limb pain that is seemingly disproportionate in time or degree to the usual course of any known trauma or other lesion. The pain is regional, with distal predominance usually but not related to a specific nerve territory or dermatome, and it is usually associated with abnormal sensory, motor, sudomotor, vasomotor and/or trophic findings. The complexity of the aetiopathogenetic factors making up the clinical picture of CRPS is mirrored by the inconsistency of almost all of the monotherapies used to treat it so far. Motor and sensory symptoms significantly interfere with the patients' daily function and quality of life, and almost all of them report substantial disability in their working and recreational activities, mood and mobility.Copyright © 2015 Elsevier Ltd. All rights reserved.

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