• Obstetrics and gynecology · Jul 1988

    Randomized Controlled Trial Comparative Study Clinical Trial

    A comparison of two antibiotic regimens for treatment of pelvic inflammatory disease.

    • D E Soper and B Despres.
    • Department of Obstetrics and Gynecology, United States Naval Hospital, Portsmouth, Virginia.
    • Obstet Gynecol. 1988 Jul 1; 72 (1): 7-12.

    AbstractSixty-two women were randomized in a double-blind fashion to receive one of two antibiotic regimens for the treatment of clinically diagnosed pelvic inflammatory disease. Thirty of 31 patients (96.8%) receiving a combination of cefoxitin with doxycycline and 28 of 31 (90.3%) receiving a combination of clindamycin with amikacin responded to therapy (P = not significant). Chlamydia trachomatis, Neisseria gonorrhoeae, or both were isolated from 13.3, 7.0, and 4.8% of patients, respectively. Of the four patients not responding to therapy, all had inflammatory complexes. Cefoxitin/doxycycline and clindamycin/amikacin are both effective in the treatment of pelvic inflammatory disease.

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