[Prospective validation of PMN-elastase as a prognostic

Unfallchirurgie · Oct 1994

[Prospective validation of PMN-elastase as a prognostic parameter in the surgical intensive care unit].

The study presented investigates prospectively the clinical value of the PMN-elastase as a sequel parameter in 954 patients of a surgical intensive care unit. The elastase-values measured discriminate highly significant between patients with and without complications (p < 0.001) as well as between survivors and non-survivors (p < 0.001). Furthermore in patients underlying shock-phases in the course of treatment significantly higher elastase values are measured as in the patients remaining (p < 0.001). The highest prognostic evidence is determined by the elastase at the 9th day of course of disease concerning the prediction of a patient's death (sensitivity 78%, specificity 75%, positive predictive value 63%, respectively negative predictive value 87%).

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- J Windolf, G Oremek, R Inglis, and A Zega.
- Unfallchirurgische Klinik, Johann-Wolfgang-Goethe-Universität Frankfurt am Main.
- Unfallchirurgie. 1994 Oct 1; 20 (5): 239-50.
AbstractThe study presented investigates prospectively the clinical value of the PMN-elastase as a sequel parameter in 954 patients of a surgical intensive care unit. The elastase-values measured discriminate highly significant between patients with and without complications (p < 0.001) as well as between survivors and non-survivors (p < 0.001). Furthermore in patients underlying shock-phases in the course of treatment significantly higher elastase values are measured as in the patients remaining (p < 0.001). The highest prognostic evidence is determined by the elastase at the 9th day of course of disease concerning the prediction of a patient's death (sensitivity 78%, specificity 75%, positive predictive value 63%, respectively negative predictive value 87%).

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[Prospective validation of PMN-elastase as a prognostic parameter in the surgical intensive care unit].

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