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Ugeskrift for laeger · Jun 2012
Case Reports[Treatment of metformin-associated lactate acidosis by haemodialysis].
- Karin Schousboe, Daniel El Fassi, Erik Lilja Secher, Hanne Elming, Knud Rasmussen, and Mads Hornum.
- Medicinsk Afdeling, Roskilde Sygehus, Køgevej 7-13, 4000 Roskilde, Denmark. karinschousboe@hotmail.com
- Ugeskr. Laeg. 2012 Jun 4; 174 (23): 1604-6.
AbstractMetformin-associated lactate acidosis is rare but serious and characterized by metabolic acidosis and elevated lactate. We describe a single-institution experience of four cases in one year. Despite pH levels of 6.85 to 7.12 and lactate levels of 11-28 mmol/l three of the patients survived. Two of the patients had normal kidney function previous to hospitalization. Treatment includes fluid replacement, IV sodium bicarbonate and haemodialysis.
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