• Solweig Guinard-Barbier, Sophie Grabar, Camille Chenevier-Gobeaux, Laurent Quinquis, Jeannot Schmidt, Gérald Kierzek, Sylvie Guérin, Pierre Hausfater, Bruno Bernot, Patrick Brun, Albéric Gayet, Enrique Casalino, Christophe Andreotti, Bertrand Renaud, and Yann-Erick Claessens.
• Department of Emergency Medicine, Groupe Hospitalier Broca Cochin Hôtel-Dieu, Paris Cedex 14, France.
• Biomarkers. 2011 Jun 1; 16 (4): 355-63.

IntroductionMid-regional pro-atrial natriuretic peptide (MRproANP) increases during systemic infections and could possibly correlate with bacteremia.MethodsWe determined the characteristics of MRproANP for accuracy to detect positive blood culture.ResultsBacteremia was positive in 58 (15%) of 347 patients. MRproANP levels increased in patients with bacteremia (98.4 pmol/L [interquartile range (IQR) 68.2-153.1] vs. 66.4 pmol/L [IQR 51.0-90.3], p <0.01). Performance of MRproANP to predict bacteremia [AUC = 0.69, 95%CI: 0.61-0.77] was equivalent to C-reactive protein (0.66 [95%CI: 0.59-0.74], p = 0.53) but less accurate than procalcitonin (0.78 [95%CI: 0.72-0.84], p <0.001).ConclusionAlthough MRproANP increased in bacteremic patients with acute pyelonephritis, results of likelihood ratios discarded its use at bedside to predict bacteremia.

24 keywords...

hide…