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- N Tomizawa, T Tsujimoto, K Itoh, T Ogino, K Nakamura, and S Hara.
- Department of Veterinary Surgery, Faculty of Agriculture, Iwate University, Japan.
- J. Vet. Med. Sci. 1997 Apr 1; 59 (4): 307-10.
AbstractEffects of a combination of medetomidine-ketamine as a chemical restraint and antagonistic effects of atipamezole on this combination were investigated in 5 lions. The medetomidine (47.6-58.4 micrograms/kg) and ketamine (1.9-5.7 mg/kg) combination provided complete immobilization with good analgesia and muscle relaxation in 4 lions, while one lioness was poorly sedated by medetomidine, and additional injections of medetomidine and ketamine were required. The duration of anesthesia seemed to be much longer than one hour in 4 of the lions. Atipamezole, at four times the preceding dose of medetomidine, provided a smooth recovery and animals were able to stand up 17-61 min after its injection. Side effects were limited to vomiting after walking in 3 of 5 lions.
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