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Technol Health Care · Apr 1996
An intravascular microdialysis sampling system suitable for application in continuous biochemical monitoring of glucose and lactate.
- K Rabenstein, A J McShane, M J McKenna, E Dempsey, T V Keaveny, and R Freaney.
- Education and Research Centre, St. Vincent's Hospital, Dublin, Ireland.
- Technol Health Care. 1996 Apr 1; 4 (1): 67-76.
AbstractDirect sensor implantation for continuous biochemical monitoring has proved disappointing, but microdialysis sampling devices can serve as a biocompatible patient-sensor interface. We propose a novel "MiniShunt" extracorporeal microdialysis sampling circuit designed to sample core blood, and report the performance of different microdialysis probe membrane types and sizes with pumped and non-pumped blood flow in anaesthetised dogs. Discrete microdialysate and plasma samples collected during glucose and lactate monitoring were analysed with a YSI analyzer and showed microdialysis efficiency (% relative recovery) in excess of 95% for both analytes using fibres of greater than 70 mm2 internal surface area. Pumped veno-venous extracorporeal blood microdialysis sampling of this type could provide a suitable interface for future multi-analyte on-line biosensor applications in critically ill patients.
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