• François Dubos, Bartosz Korczowski, Denizmen A Aygun, Alain Martinot, Cristina Prat, Annick Galetto-Lacour, Juan Casado-Flores, Erdal Taskin, Francis Leclerc, Carlos Rodrigo, Alain Gervaix, Dominique Gendrel, Gérard Bréart, and Martin Chalumeau.
• Department of Pediatrics, Saint-Vincent-de-Paul Hospital, 74-82 avenue Denfert-Rochereau, 75014 Paris, France.
• Arch. Dis. Child. 2010 Dec 1; 95 (12): 963-7.

BackgroundClinical decision rules (CDRs) could be helpful to safely distinguish between bacterial and aseptic meningitis (AM).ObjectiveTo compare the performance of two of these CDRs for children: the Bacterial Meningitis Score (BMS) and the Meningitest.DesignSecondary analysis of retrospective multicentre hospital-based cohort study.SettingSix paediatric emergency or intensive care units of tertiary care centres in five European countries.PatientsConsecutive children aged 29 days to 18 years presenting with acute meningitis and procalcitonin (PCT) measurement. Intervention None.Main Outcome MeasuresThe sensitivity and specificity of the BMS (start antibiotics in case of seizure, positive cerebrospinal fluid (CSF) Gram staining, blood neutrophil count ≥10 ×10(9)/l, CSF protein level ≥80 mg/dl or CSF neutrophil count ≥1000 ×10(6)/l) and the Meningitest (start antibiotics in case of seizure, purpura, toxic appearance, PCT level ≥0.5 ng/ml, positive CSF Gram staining or CSF protein level ≥50 mg/dl) were compared using a McNemar test.Results198 patients (mean age 4.8 years) from six centres in five European countries were included; 96 had bacterial meningitis. The BMS and Meningitest both showed 100% sensitivity (95% CI 96% to 100%). The BMS had a significantly higher specificity (52%, 95% CI 42% to 62% vs 36%, 95% CI 27% to 46%; p<10(-)8).ConclusionThe Meningitest and the BMS were both 100% sensitive. This result provides level II evidence for the sensitivity of both rules, which can be used cautiously. However, use of the BMS could safely avoid significantly more unnecessary antibiotic treatments for children with AM than can the Meningitest in this population.

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