• Eija Rosti-Otajärvi, Anu Mäntynen, Keijo Koivisto, Heini Huhtala, and Päivi Hämäläinen.
• Tampere University Hospital, Department of Neurology and Rehabilitation, P.O. Box 2000, 33521 Tampere, Finland. Electronic address: eija.rosti-otajarvi@pshp.fi.
• J. Neurol. Sci. 2013 Nov 15; 334 (1-2): 154-60.

BackgroundSystematic reviews have indicated a low level of evidence for the positive effects of neuropsychological and cognitive rehabilitation in multiple sclerosis (MS). How permanent the positive effects are, is unknown.ObjectiveThe aim of the present study was to evaluate whether short-term neuropsychological rehabilitation has long-term beneficial effects in a nine-month follow-up.Methods102 relapsing-remitting MS patients with subjective and objective attentional deficits were randomized into intervention and control groups. Altogether 78 out of 102 patients (76%) completed the longitudinal follow-up (intervention group 83%, control group 67%). Intervention group received strategy-oriented neuropsychological rehabilitation conducted once a week in 60-minute sessions during thirteen consecutive weeks. The control group received no intervention. Cognitive deficits, mood, fatigue, impact of disease, and quality of life were evaluated with self-reports at baseline, six months, and one year from baseline.ResultsThe positive effects of neuropsychological rehabilitation on perceived cognitive deficits were maintained for nine months. Among a subgroup of patients with moderate to severe attentional deficits, positive rehabilitation outcome was even more evident.ConclusionThe beneficial effects of strategy-oriented neuropsychological rehabilitation on perceived cognitive deficits in MS may be maintained for at least one year after the beginning of the intervention.© 2013 Elsevier B.V. All rights reserved.

30 keywords...

hide…