• Ophthalmology · Nov 1990

    Randomized Controlled Trial Clinical Trial

    Bicarbonate-buffered lidocaine-epinephrine-hyaluronidase for eyelid anesthesia.

    • S G Eccarius, M E Gordon, and J J Parelman.
    • Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110.
    • Ophthalmology. 1990 Nov 1; 97 (11): 1499-501.

    AbstractA double-masked, randomized clinical trial was conducted to determine if subcutaneous eyelid injections of a bicarbonate-buffered lidocaine-epinephrine-hyaluronidase mixture were less painful than unbuffered injections. Twenty-one patients received both buffered (pH = 7.4) and unbuffered (pH = 4.6) injections. After each injection, patients recorded pain on a scale of 0, "no pain," to 10, "severe pain." Mean pain score for buffered injections was 2.0 versus 4.1 for unbuffered injections (P = 0.0003). Seventeen (81%) of 21 patients ranked the buffered injection less painful. Use of a bicarbonate-buffered lidocaine-epinephrine-hyaluronidase mixture is effective in making ophthalmic anesthesia less painful.

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