• Yolanda Chik, Robert E Hoesch, Christos Lazaridis, Carla J Weisman, and Rafael H Llinas.
• Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
• Nat Rev Neurol. 2009 Sep 1; 5 (9): 512-6.

BackgroundA 33-year-old woman experienced a thunderclap headache immediately postpartum. The headache recurred over the next 10 days, and the patient also developed generalized tonic-clonic seizures. A subarachnoid hemorrhage was demonstrated on a head CT scan.InvestigationsPhysical examination, laboratory tests, brain CT scan, brain MRI scan, brain magnetic resonance angiogram, brain magnetic resonance venogram, cerebral angiography, transcranial Doppler ultrasound, EEG.DiagnosisPostpartum cerebral angiopathy.ManagementNSAIds and opioid analgesics administered on postpartum day 3 provided partial headache relief. The next day, a blood patch was performed and intravenous caffeine, fluid and opioid analgesia were given to treat a suspected dural puncture headache. Following diagnosis of postpartum cerebral angiopathy on postpartum day 10, nimodipine was initiated to treat the vasospasm, and the headache was treated with opioid analgesics and toradol, followed by naproxen. The patient also received a 3-day course of intravenous magnesium sulfate.

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