• Shuai-Shuai Hu, Hong-Gang Zhang, Qiu-Ju Zhang, and Rui-Juan Xiu.
• Institute of Microcirculation, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Microcirculation, National Health and Family Planning Commission, Beijing, China.
• Plos One. 2014 Jan 1; 9 (8): e104528.

ObjectivesSeveral recent lines of evidence indicate that endothelial microparticles are a new biomarker that can be used to monitor endothelial dysfunction in coronary artery disease (CAD). However, data concerning the detection of small microparticles (diameter <0.5 µm) are lacking. The aim of this study was to detect small-size endothelial microparticles (SEMPs) in CAD patients to monitor endothelial dysfunction.MethodsIn total, 19 CAD patients and 14 healthy subjects were recruited. The absolute numbers and percentages of CD31(+)/CD42b- SEMPs and CD62E(+) SEMPs were determined by flow cytometry. Clinical parameters were also recorded.ResultsThe mean percentage of CD62E(+) SEMPs was higher in the CAD patient group than in the healthy subject group. The area under the receiver operating characteristic curve of the percentage of CD62E(+) SEMPs was 0.795, and the cut-off value was 1.35. There was no correlation between the percentage of CD62E(+) SEMPs and various clinical parameters.ConclusionThe percentage of CD62E(+) SEMPs is a potential biomarker for monitoring endothelial function in CAD.

29 keywords...

hide…