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Cancer treatment reviews · Feb 2010
ReviewCombined treatment strategies in gastrointestinal stromal tumors (GISTs) after imatinib and sunitinib therapy.
- Maria Abbondanza Pantaleo, Margherita Nannini, Monica Di Battista, Fausto Catena, and Guido Biasco.
- Department of Hematology and Oncological Sciences "L.A. Seragnoli", S. Orsola-Malpighi Hospital, University of Bologna, Italy. maria.pantaleo@unibo.it
- Cancer Treat. Rev. 2010 Feb 1; 36 (1): 63-8.
AbstractResistance to tyrosine-kinase inhibitors remains an open issue in the treatment of patients with gastrointestinal stromal tumors. The complex biology of disease in the multi-resistant setting has led a progressively growing urgency and interest in development combined or integrated therapies. This mini-review outlines the rationale for developing new combined therapeutic approaches, and describes the state of the art of the various potential strategies and the promising research perspectives.2009 Elsevier Ltd. All rights reserved.
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