• Anaesthesia · Sep 1990

    Case Reports

    Prolonged neuromuscular blockade with vecuronium in a neonate with renal failure.

    • S R Haynes and N S Morton.
    • Department of Anaesthesia, Royal Hospital for Sick Children, Yorkhill, Glasgow.
    • Anaesthesia. 1990 Sep 1; 45 (9): 743-5.

    AbstractAn 11-day-old neonate with renal failure caused by dysplastic kidneys was anaesthetised with thiopentone, vecuronium, nitrous oxide and oxygen, for insertion of a long-term peritoneal dialysis catheter. Complete neuromuscular block of 210 minutes' duration ensued after the initial dose of vecuronium (97 micrograms/kg). Partial block persisted for a further 30 minutes. The prolonged neuromuscular block in this case may have been because of proportionately greater dependence on renal clearance of vecuronium in neonates.

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