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- H B Reith, S K Rauchschwalbe, U Mittelkötter, R Engemann, A Thiede, A Arnold, and R Lissner.
- Department of Surgery, Klinikum Konstanz, Luisenstrasse 7, D-78464-Konstanz, Germany. bernd.reith@klinikum-konstanz.de
- Eur. J. Med. Res. 2004 Oct 29; 9 (10): 479-84.
BackgroundPolyvalent IgM-enriched intravenous human immunoglobulin (IVIG) preparations are discussed to be beneficial regarding sepsis outcome.Materials And MethodsSixty-four patients with abdominal infection were treated with Pentaglobin or Albumin. Serum levels of endotoxin and chemokines were determined.ResultsIncidence of fever was 19/28 in the pentaglobin and 18/26 in the albumin group, the percentage of days with fever was 34 +/- 26 for pentaglobin and 43 +/- 25 for albumin (mean +/-SD). Procalcitonin levels of the pentaglobin treated patients fell under the upper limit of normal on day six whereas levels of albumin patients remained elevated.ConclusionPentaglobin has a positive influence on the course of post-surgery intra-abdominal infection.
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