• Carla R Jungquist, Chris Pasero, Nicole M Tripoli, Rachel Gorodetsky, Mark Metersky, and Rosemary C Polomano.
• Assistant Professor, University at Buffalo, the State University of New York, Buffalo, NY, USA.
• Worldviews Evid Based Nurs. 2014 Dec 1; 11 (6): 350-60.

BackgroundAdverse events related to opioid-induced unintended advancing sedation and respiratory depression in hospitalized patients are occurring with increased frequency, and these adverse events can have a negative impact on quality and cost outcomes.AimThe goal of this paper is to inform nurses on best practices for preventing opioid-induced advancing sedation and respiratory depression, and to inform nurse leaders on implementation strategies to guide change in policies and practice.MethodsThis paper presents an evidenced-based systematic approach for organizations to use in implementing strategies to reduce adverse events secondary to opioid-induced advancing sedation and respiratory depression in the hospitalized adult patient.ResultsAn action-oriented framework was developed based on the authors' experiences, strategies recommended by the Institute for Healthcare Improvement (IHI), the National Association of Healthcare Quality (NAHQ), and expert consensus-based best monitoring practices.Linking Evidence To ActionNurse executives and nurse managers assume accountability for ensuring that patient care is aligned with the best evidence, practices, and regulatory mandates. The framework presented in this paper can help prevent opioid-induced advancing sedation and respiratory depression, and assist nurse leaders in implementation strategies to guide policies and practice.© 2014 Sigma Theta Tau International.

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