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Expert Rev Clin Pharmacol · May 2014
ReviewA perspective on the epidemiology of acetaminophen exposure and toxicity in the United States.
- Marissa Blieden, L Clark Paramore, Dhvani Shah, and Rami Ben-Joseph.
- Evidera, 430 Bedford St, Suite 300, Lexington, MA 02420, USA.
- Expert Rev Clin Pharmacol. 2014 May 1; 7 (3): 341-8.
AbstractAcetaminophen is a commonly-used analgesic in the US and, at doses of more than 4 g/day, can lead to serious hepatotoxicity. Recent FDA and CMS decisions serve to limit and monitor exposure to high-dose acetaminophen. This literature review aims to describe the exposure to and consequences of high-dose acetaminophen among chronic pain patients in the US. Each year in the US, approximately 6% of adults are prescribed acetaminophen doses of more than 4 g/day and 30,000 patients are hospitalized for acetaminophen toxicity. Up to half of acetaminophen overdoses are unintentional, largely related to opioid-acetaminophen combinations and attempts to achieve better symptom relief. Liver injury occurs in 17% of adults with unintentional acetaminophen overdose.
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