• Connecticut medicine · Oct 2004

    Case Reports

    Successful treatment of hydromorphone-induced neurotoxicity and hyperalgesia.

    • Keun Sam Chung, Shawn Carson, David Glassman, and Nalini Vadivelu.
    • Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06520, USA.
    • Conn Med. 2004 Oct 1; 68 (9): 547-9.

    AbstractThere has been an increase in opioid consumption world wide in the last decade. There has also been a disturbing increase in the number of reports of neuroexcitatory opioid-related side effects observed in patients receiving large doses of systemically administered morphine and its structural analogue, hydromorphone. It is now becoming clearer that patients receiving long-term opioid therapy can develop unexpected pain. We describe an interesting case of successful management of hydromorphone-induced neurotoxicity and hyperalgesia produced by short-term therapy with rapidly escalating doses of systemic hydromorphone.

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