• Acta neurochirurgica · Dec 2001

    Clinical Trial

    Effect of nitrous oxide on spike activity during epilepsy surgery.

    • Y Sato, K Sato, H Shamoto, M Kato, and T Yoshimoto.
    • Department of Neuroanesthesia, Kohnan Hospital, Japan.
    • Acta Neurochir (Wien). 2001 Dec 1; 143 (12): 1213-5; discussion 1215-6.

    AbstractThere are controversies over the effect of nitrous oxide on the electrocorticograms in patients with epilepsy. To clarify the effect of nitrous oxide on electrocorticograms, spike activities were compared with and without nitrous oxide under neuroleptoanesthesia in 10 patients with intractable epilepsy during surgery. Spikes decreased with nitrous oxide significantly (P<0.01) and disappeared in 3 cases. We conclude that discontinuation of nitrous oxide should be taken into consideration during electrocorticographic monitoring in epilepsy surgery.

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