• J S Young and J W Meredith.
• Department of General Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
• Am Surg. 1995 May 1; 61 (5): 419-23.

AbstractThere is concern that oxygen delivery-directed resuscitation in patients with multiple trauma, including severe head injury, may worsen neurologic recovery. To study this, we retrospectively examined 31 patients admitted over an 18-month period who met the inclusion criteria of having suffered blunt trauma, were between 15 and 65 years of age, had an admission Glasgow coma scale of < or = 8, intact corneal and gag reflexes, and extracranial injury with an Abbreviated Injury score of > or = 3. All patients were placed on intracranial pressure monitors. In comparing the 14 patients whose resuscitation was guided by oxygen delivery (DO2) with the 17 who were resuscitated by standard fluid restriction (FR), we found that despite the DO2 group's having received a significantly greater volume of resuscitation fluids in the first 48 hours after injury, there was no difference in the neurologic recovery between the two groups.

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