• Larissa de Freitas Bonomo, David Nunes Silva, Patrícia Ferreira Boasquivis, Franciny Aparecida Paiva, Joyce Ferreira da Costa Guerra, Talita Alves Faria Martins, Álvaro Gustavo de Jesus Torres, Igor Thadeu Borges Raposo de Paula, Washington Luiz Caneschi, Philippe Jacolot, Nicolas Grossin, Frederic J Tessier, Eric Boulanger, Marcelo Eustáquio Silva, Maria Lúcia Pedrosa, and Riva de Paula Oliveira.
• Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.
• Plos One. 2014 Jan 1; 9 (3): e89933.

AbstractAçaí (Euterpe oleracea Mart.) has recently emerged as a promising source of natural antioxidants. Despite its claimed pharmacological and nutraceutical value, studies regarding the effects of açaí in vivo are limited. In this study, we use the Caenorhabditis elegans model to evaluate the in vivo antioxidant properties of açaí on an organismal level and to examine its mechanism of action. Supplementation with açaí aqueous extract (AAE) increased both oxidative and osmotic stress resistance independently of any effect on reproduction and development. AAE suppressed bacterial growth, but this antimicrobial property did not influence stress resistance. AAE-increased stress resistance was correlated with reduced ROS production, the prevention of sulfhydryl (SH) level reduction and gcs-1 activation under oxidative stress conditions. Our mechanistic studies indicated that AAE promotes oxidative stress resistance by acting through DAF-16 and the osmotic stress response pathway OSR-1/UNC-43/SEK-1. Finally, AAE increased polyglutamine protein aggregation and decreased proteasome activity. Our findings suggest that natural compounds available in AAE can improve the antioxidant status of a whole organism under certain conditions by direct and indirect mechanisms.

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