• Journal of critical care · Jun 2015

    Glucose control positively influences patient outcome: A retrospective study.

    • Sophie Penning, Chris Pretty, Jean-Charles Preiser, Geoffrey M Shaw, Thomas Desaive, and J Geoffrey Chase.
    • GIGA-Cardiovascular Sciences, Institut de Physique, Université de Liege, Institut de Physics, Allée du 6 Août, 17 (Bât B5), B4000 Liege, Liege, Belgium. Electronic address: Sophie.Penning@ulg.ac.be.
    • J Crit Care. 2015 Jun 1;30(3):455-9.

    ObjectiveThe goal of this research is to demonstrate that well-regulated glycemia is beneficial to patient outcome, regardless of how it is achieved.MethodsThis analysis used data from 1701 patients from 2, independent studies. Glycemic outcome was measured using cumulative time in band (cTIB), calculated for 3 glycemic bands and for threshold values of t = 0.5, 0.6, 0.7, and 0.8. For each day of intensive care unit stay, patients were classified by cTIB, threshold, and hospital mortality, and odds of living (OL) and odds ratio were calculated.ResultsThe OL given cTIB ≥ t is higher than the OL given cTIB 0.6. Higher cTIB thresholds resulted in larger increases to odds ratio over time and were particularly significant for the 4.0 to 7.0 mmol/L glycemic band.ConclusionIncreased cTIB was associated with higher OL. These results suggest that effective glycemic control positively influences patient outcome, regardless of how the glycemic regulation is achieved. Blood glucose < 7.0 mmol/L is associated with a measurable increase in the odds of survival, if hypoglycemia is avoided.Copyright © 2015 Elsevier Inc. All rights reserved.

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