• Whitney Y Hung, Laura Kogelman, Gretchen Volpe, Mark Iafrati, and Lisa Davidson.
• Department of Pharmacy, 800 Washington Street, Tufts Medical Center #420, Boston, MA 02111, USA. whitney0522@gmail.com
• Int. J. Antimicrob. Agents. 2009 Nov 1; 34 (5): 486-9.

AbstractTigecycline is a broad-spectrum antimicrobial agent structurally related to minocycline. Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised. We describe a 69-year-old female who received tigecycline for treatment of a complicated skin and skin-structure infection. Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis. According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis. Clinicians should be aware of this potential adverse effect of tigecycline. We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.

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