• Samad Shams Vahdati, Hamid Reza Morteza Baghi, Jaffar Ghobadi, Rouzbeh Rajaei Ghafouri, and Paria Habibollahi.
• Emergency Department, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
• Anesth Pain Med. 2014 Aug 1; 4 (3): e14903.

BackgroundThis randomized, clinical trial evaluates the analgesic and safety of paracetamol and Morphine in management of headache.ObjectivesThis study aimed to evaluate the analgesic and safety effects of intravenous single dose of paracetamol, versus morphine in post trauma headache in emergency departments.Patients And MethodsThis study was a single-center, prospective, randomized, double-blind clinical trial conducted on two groups treated with intravenous paracetamol and intravenous morphine. Thirty patients were enrolled in each group. Patients (18-55 years-old adults) complaining from headaches due to pure trauma were included in the study. The inclusion criteria required patients to have headachesof more than 40 mm on a 100 mm visual analogue scale without any pathological findings in their clinical examinations and imaging studies.ResultsMean duration required to treat the headache was 37.43 and 71.93 minutes in the groups administered paracetamol (group A) and morphine (group B), respectively. After 15 minutes of treatment, this changed to 31.7 ± 18.0 mm (95% CI 8.2 to 25.2) and 48.3 ± 14.1 mm (95% CI 8.2 to 25.2) in groups A and B, respectively. Headache of the patients of group A significantly mitigated in comparison with group B (P < 0.005). Headache of group Apatients was significantly mitigated 30 minutes after treatment (P < 0.005).ConclusionsIntravenous paracetamol is an effective and safe treatment for patients admitted to the emergency department with headaches caused by head trauma.

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