• Statistics in medicine · Nov 2008

    Sample size calculation for cluster randomized cross-over trials.

    • B Giraudeau, P Ravaud, and A Donner.
    • INSERM, CIC 202, France. giraudeau@med.univ-tours.fr
    • Stat Med. 2008 Nov 29; 27 (27): 5578-85.

    AbstractThe cluster randomized cross-over design has been proposed in particular because it prevents an imbalance that may bring into question the internal validity of parallel group cluster trials. We derived a sample size formula for continuous outcomes that takes into account both the intraclass correlation coefficient (representing the clustering effect) and the interperiod correlation (induced by the cross-over design).Copyright (c) 2008 John Wiley & Sons, Ltd.

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