• J R Soc Med · Oct 2000

    Sonoclot coagulation analysis of in-vitro haemodilution with resuscitation solutions.

    • E V Brazil and T J Coats.
    • Accident and Emergency Department, Royal London Hospital, Whitechapel, UK.
    • J R Soc Med. 2000 Oct 1; 93 (10): 507-10.

    AbstractThe colloid and crystalloid solutions used for resuscitation should preferably be free from effects on coagulation. In 10 volunteers, the effects of haemodilution with various concentrations of 0.9% sodium chloride and 4% succinylated gelatin were assessed by Sonoclot analysis, which describes the whole coagulation process. Small and moderate haemodilution (up to 40%) with 0.9% sodium chloride promoted coagulation. Similar haemodilution with 4% succinylated gelatin impaired coagulation, and at 60% haemodilution coagulation was very poor. These findings need to be confirmed in vivo and their clinical relevance determined.

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