• West. J. Med. · Apr 1996

    Review

    Endemic mycosis complicating human immunodeficiency virus infection.

    • G A Sarosi and S F DAvies.
    • Santa Clara Valley Medical Center, San Jose, California, USA.
    • West. J. Med. 1996 Apr 1; 164 (4): 335-40.

    AbstractPersons infected with the human immunodeficiency virus are prone to the development of many fungal diseases. Normal hosts with intact immunity usually recover from infection by these less-invasive fungi. In persons with compromised T-cell-mediated immunity, however, widespread dissemination from a pulmonary focus occurs. In this review, we discuss the epidemiology, clinical manifestations, diagnosis, and treatment of the three major North American mycoses, histoplasmosis, blastomycosis, and coccidioidomycosis. In most cases, amphotericin B is the initial drug of choice, followed by one of the azoles for lifelong maintenance therapy.

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