• S R Durham, R Raghupathi, M A Helfaer, S Marwaha, and A C Duhaime.
• Department of Neurosurgery, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pa., USA. durhamsr@mail.med.upenn.edu
• Pediatr Neurosurg. 2000 Aug 1; 33 (2): 76-82.

IntroductionThe goal of the present study was to determine whether age-related differences in the acute physiologic response to scaled cortical impact injury contribute to differences in vulnerability to traumatic brain injury (TBI).MethodsHeart rate (HR), mean arterial pressure (MAP), brain temperature (BrT) and cerebral blood flow (CBF) were measured in 22 piglets (7 of age 5 days, 8 of age 1 month, 7 of age 4 months) at baseline and for 3 h following scaled cortical impact injury.ResultsThere were no age-dependent variations from baseline in HR, MAP or BrT following injury. CBF increased in the 5-day-old animals following injury while CBF in the 1- and 4-month-old animals decreased following injury (p = 0.0049).ConclusionCBF was shown to have a significant age-dependent response to TBI with the youngest animals exhibiting increased CBF following injury.Copyright 2000 S. Karger AG, Basel.

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