• Chun Wing Yeung, Ho Yin Chung, Bonnie Mei Wah Fong, Nga Wing Tsai, Wai Ming Chan, Tak Shing Siu, Sidney Tam, and Sik Hon Tsui.
• Division of Clinical Biochemistry, Queen Mary Hospital, Hong Kong, SAR, China. ycw186 @ ha.org.hk
• Pharmacology. 2011 Jan 1; 88 (5-6): 260-5.

AbstractMetformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to demonstrate the epidemiological data, risk factors, clinical features as well as the clinical outcomes for better understanding of this disease entity. It is the first MALA case series in which plasma metformin levels were assessed. However, the results show that plasma metformin levels in MALA bear no diagnostic and prognostic values. Risk factors of mortality were identified as shock and high plasma lactate levels. The majority of patients were found to have significantly raised creatinine versus a normal baseline value before the acute illness. Concomitant illnesses taking place alongside MALA were common. With a high utility rate of renal replacement therapy (82.6%) in the study group, the mortality rate was 30.4%.Copyright © 2011 S. Karger AG, Basel.

42 keywords...

hide…