• Bulletin du cancer · Feb 2006

    Review

    Desmopressin and other synthetic vasopressin analogues in cancer treatment.

    • Daniel E Gomez, Giselle V Ripoll, Santiago Girón, and Daniel F Alonso.
    • Laboratory of Molecular Oncology, Department of Science and Technology Quilmes National University, R. Saenz Peña 180, Bernal (1876), Buenos Aires, Argentina. degomez@unq.edu.ar
    • Bull Cancer. 2006 Feb 1; 93 (2): E7-12.

    AbstractDesmopressin (DDAVP) is a well tolerated and convenient haemostatic agent that can be used in a number of clinical conditions with bleeding diathesis. It has several effects on the haemostatic system, causing endogenous release of coagulation factor VIII, von Willebrand factor and tissue-type plasminogen activator, among others. In this review we present a growing body of evidence showing that DDAVP treatment may impair spread of cancer cells and contribute to encapsulation of tumour tissue. Our data in preclinical animal models suggest a potential application of DDAVP in the perioperative management of aggressive solid tumours. Novel vasopressin analogues with improved antitumor effects are currently in development.

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