• Douglas Zatzick, Peter Roy-Byrne, Joan Russo, Frederick Rivara, RoseAnne Droesch, Amy Wagner, Chris Dunn, Gregory Jurkovich, Edwina Uehara, and Wayne Katon.
• Department of Psychiatry and Behavioral Sciences, the Harborview Injury Prevention and Research Center, University of Washington School of Medicine, Seattle 98104, USA. dzatzick@u.washington.edu
• Arch Gen Psychiat. 2004 May 1; 61 (5): 498-506.

ContextAlthough posttraumatic stress disorder (PTSD) and alcohol abuse frequently occur among acutely injured trauma survivors, few real-world interventions have targeted these disorders.ObjectiveWe tested the effectiveness of a multifaceted collaborative care (CC) intervention for PTSD and alcohol abuse.DesignRandomized effectiveness trial.ParticipantsWe recruited a population-based sample of 120 male and female injured surgical inpatients 18 or older at a level I trauma center.InterventionPatients were randomly assigned to the CC intervention (n = 59) or the usual care (UC) control condition (n = 61). The CC patients received stepped care that consisted of (1) continuous postinjury case management, (2) motivational interviews targeting alcohol abuse/dependence, and (3) evidence-based pharmacotherapy and/or cognitive behavioral therapy for patients with persistent PTSD at 3 months after injury.Main Outcome MeasuresWe used the PTSD symptomatic criteria (PTSD Checklist) at baseline and 1, 3, 6, and 12 months after injury, and alcohol abuse/dependence (Composite International Diagnostic Interview) at baseline and 6 and 12 months after injury.ResultsRandom-coefficient regression analyses demonstrated that over time, CC patients were significantly less symptomatic compared with UC patients with regard to PTSD (P =.01) and alcohol abuse/dependence (P =.048). The CC group demonstrated no difference (-0.07%; 95% confidence interval [CI], -4.2% to 4.3%) in the adjusted rates of change in PTSD from baseline to 12 months, whereas the UC group had a 6% increase (95% CI, 3.1%-9.3%) during the year. The CC group showed on average a decrease in the rate of alcohol abuse/dependence of -24.2% (95% CI, -19.9% to -28.6%), whereas the UC group had on average a 12.9% increase (95% CI, 8.2%-17.7%) during the year.ConclusionsEarly mental health care interventions can be feasibly and effectively delivered from trauma centers. Future investigations that refine routine acute care treatment procedures may improve the quality of mental health care for Americans injured in the wake of individual and mass trauma.

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