• Md RalibAzrinaADepartment of Anaesthesiology and Intensive Care, Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia, Jalan Hospital Campus, Kuantan, Pahang, Malaysia 25000. Electronic address: drazrina@gmail.com. and Mohd Basri Mat Nor.
• Department of Anaesthesiology and Intensive Care, Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia, Jalan Hospital Campus, Kuantan, Pahang, Malaysia 25000. Electronic address: drazrina@gmail.com.
• J Crit Care. 2015 Jun 1; 30 (3): 636-42.

PurposeAcute kidney injury (AKI) is common and carries a high mortality rate. Most epidemiological studies were retrospective and were done in Western populations. We aim to assess its incidence using both urine output and creatinine criteria and its association with risk factors and outcome.Material And MethodsThis was a single-center, prospective, observational study. All intensive care unit (ICU) patients older than 18 years were screened for inclusion in the study. Admission of less than 48 hours, postelective surgery, and ICU readmission were excluded.ResultsA total of 143 patients were recruited, of these, 65% had AKI, of which 18 (19%) were stage 1; 23 (25%), stage 2; and 52 (56%), stage 3. Independent risk factors for AKI include high Acute Physiology and Chronic Health Evaluation II score and septic shock (odds ratio of 1.20 [1.09-1.33] and 8.41 [1.49-47.6], respectively). Thirty-eight percent were classified as AKI based on creatinine and 61% as AKI based on urine output criteria, and, in 34%, both AKI based on creatinine and AKI based on urine output criteria were present. Acute kidney injury was an independent risk factor for mortality (hazard ratio of, 2.61 [1.06-6.42]).ConclusionsAcute kidney injury is common in our ICU, and almost half are of highest severity stage. Patients with high severity of illness and septic shock were at risk for AKI. The presence of AKI independently predicted mortality.Copyright © 2015 Elsevier Inc. All rights reserved.

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