• T Yamakawa, S Yamaguchi, H Niimi, and I Sugiyama.
• National Cardiovascular Center Research Institute, Osaka, Japan.
• Circ. Shock. 1987 Jan 1; 22 (4): 323-32.

AbstractThe behavior of white blood cells (WBCs) in the capillary network of the cat brain was studied under normal conditions and during acute hemorrhagic hypotension. A small transilluminated area of the cerebral cortex was observed directly, and blood cells flowing through the capillary network were recorded on cinefilm using a high-speed cinecamera. The cell motion was analyzed on the projection screen using a frame-by-frame method. The time during which a single WBC remained at a capillary branching, ie, stagnant time (ST) was examined in detail. In hemorrhagic hypotension, ST was much longer than that in the normal condition. WBC plugging occurred at capillary branchings, and a nonuniform flow pattern (plasma-WBC-accumulated red blood cells [RBCs]) appeared in perfused capillaries. RBC velocity in capillaries was reduced. The ST level was increased significantly with a decrease in RBC velocity. These findings suggest that acute hemorrhagic hypotension may induce flow maldistribution in cerebral microcirculation.

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