• Masako Kinoshita, Akio Ikeda, Riki Matsumoto, Tahamina Begum, Keiko Usui, Junichi Yamamoto, Masao Matsuhashi, Motohiro Takayama, Nobuhiro Mikuni, Jun Takahashi, Susumu Miyamoto, and Hiroshi Shibasaki.
• Departments of Neurology, Graduate School of Medicine, Kyoto Universtiy, Kyoto, Japan.
• Epilepsia. 2004 Jul 1; 45 (7): 787-91.

PurposeTo investigate underlying mechanisms and adequate parameters for electric cortical stimulation to inhibit epileptic focus in humans.MethodsA patient with intractable partial epilepsy had subdural electrodes implanted for preoperative evaluation. Cortical functional mapping was performed by using 50-Hz alternating square pulse of 0.3-ms duration, 1 to 7 mA, within 5 s. Spike frequency and electrocorticogram (ECoG) power spectra were compared before and after the stimulation when epileptic focus and distant area were stimulated. A similar comparison also was performed in low-frequency stimulation of 0.9 Hz applied for 15 min.ResultsInterictal spikes were reduced after electric cortical stimulation of the epileptic area at a frequency of 50 Hz as well as 0.9 Hz, with concomitant decrease in the electrographic fast activities at 50-Hz stimulation.ConclusionsThese data suggest that electric cortical stimulation at both high and low frequency has a suppressive effect on epileptic activities in human cortex, possibly through distinct mechanisms.Copyright 2004 International League Against Epilepsy

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